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我们继血清Ⅲ型前胶原(PCⅢ)放免法成功地建立之后,最近又建立了血清Ⅰ型前胶原(PCI)放免法并初步应用于临床。肝脏中胶原成份以Ⅰ、Ⅲ型为主,当肝纤维化时,两者都可增加但程度不一,因此血清中的浓度不完全平行。同时测定对诊断可互补,并对判断肝纤维化发展的不同阶段
Following the successful establishment of radioimmunoassay of serum type III procollagen (PCIII), we recently established a serum type I procollagen (PCI) radioimmunoassay for initial clinical use. Collagen in the liver is mainly composed of type I and type III. When liver fibrosis, both can increase but the degree is different, so the serum concentration is not completely parallel. Simultaneous determination of the diagnosis of complementary, and to determine the different stages of liver fibrosis