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在应用大剂量青霉素后可发生特征性的脑病,但很少发生.这种脑病包括嗜睡、一过性幻觉、反射亢进和肌阵挛等.在某些情况下,肌阵挛可发展到局限性癫痫、全身惊厥和昏迷.因需要如此大剂量抗菌素的患者多病情危重,故此神经毒性作用使治疗更趋复杂.了解神经毒性反应的诱发因素在临床上很重要.青霉素的作用部位在中枢神经系统(CNS),直接对大脑皮质敷用抗菌素和在脑内、脑室内和脑池内注射青霉素引起人和数种动物发生惊厥.在癫痫的实验研究中常用青霉素来诱发.青霉素中枢作用确切的细胞
Ocular encephalopathy can occur after high-dose penicillin, but rarely occurs.This encephalopathy, including drowsiness, a hallucination, hyperreflexia and myoclonus, etc. In some cases, myoclonus can develop to the limitations Epilepsy, convulsions and coma because of the need for such high doses of antibiotics in patients with multiple conditions critically ill, so the neurotoxic effect of the treatment more complicated to understand the neurotoxic response induced factor is clinically important penicillin role in the central nervous system System (CNS), direct application of antibiotics to the cerebral cortex and penicillin in the brain, intraventricular and cisternal cells cause seizures in humans and several animals. Penicillin is commonly used in experimental studies of epilepsy to induce penicillin-centered cells