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目的 :探讨粘附分子ICAM - 1、VCAM - 1在人肝细胞癌中的表达及其与肝细胞癌侵袭性的关系。方法 :采用免疫组织化学方法 (SABC)探讨二者在正常肝组织、肝海绵状血管瘤和 36例不同侵袭性肝细胞癌中的表达 ,并分析其与HCC侵袭性的关系。结果 :ICAM - 1和VCAM - 1在正常肝组织无表达 ,在 6例肝海绵状血管瘤中仅 1例VCAM - 1呈弱阳性表达 ;在 36例肝细胞癌中 ,ICAM - 1、VCAM - 1分别有 2 5例 (6 9.4% )和2 3例 (6 3 .9% )表达 ,且多数呈强阳性表达 ,明显高于癌旁组织的阳性表达率 (33 .3%和 2 6 .7% )。高侵袭肝癌组 (2 1例 )中分别有 18例 (85 .7% )和 17例 (80 .9% )表达ICAM - 1和VCAM - 1,而非侵袭组仅分别有 7例(4 6 .7% )和 6例 (4 0 .0 % )表达 ,其差异有显著意义 (P <0 .0 5 )。结论 :ICAM - 1、VCAM - 1与肝细胞癌生物恶变及侵袭性具有相关性
Objective: To investigate the expression of adhesion molecules ICAM-1 and VCAM-1 in human hepatocellular carcinoma and their relationship with the invasiveness of hepatocellular carcinoma. METHODS: Immunohistochemistry (SABC) was used to investigate the expression of the two in normal liver tissue, hepatic cavernous hemangioma, and 36 different invasive hepatocellular carcinomas, and their relationship with HCC invasiveness was analyzed. RESULTS: ICAM-1 and VCAM-1 were not expressed in normal liver tissues. In 6 cases of hepatic cavernous hemangioma, only 1 case showed weak positive expression of VCAM-1. In 36 cases of hepatocellular carcinoma, ICAM-1 and VCAM- 1 There were 25 cases (6.4%) and 23 cases (63.9%), respectively, and most of them were strongly positive, which was significantly higher than the positive rate of adjacent tissues (33. 3% and 2 6. 7%). In the high-invasion liver cancer group (21 cases), 18 cases (85.7%) and 17 cases (80.9%) expressed ICAM-1 and VCAM-1, respectively, whereas the non-invasive group had only 7 cases (4 of 6 cases). The difference was statistically significant (P < 0.05) in .7% and 6 cases (40%). Conclusion : ICAM-1 and VCAM-1 are related to the malignant and invasiveness of hepatocellular carcinoma