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目的:探讨补土益水汤对去卵巢致骨质疏松症大鼠的作用。方法:以切除雌性大鼠双侧卵巢诱导骨质疏松为模型,观察补土益水汤对大鼠血清钙、磷含量,碱性磷酸酶(Alkalin phosphatase,ALP)、骨钙素(Bone Glaprotein,BGP)、抗酒石酸酸性磷酸酶(Tartrate-resisitant acid phosphatase,TRACP)含量测定,尿吡啶啉(Pyridinoline,PYD)/尿肌酐(Creatinine,Cr)及骨密度(Bone mineral density,BMD)等指标的影响。结果:补土益水汤可显著降低血清ALP、TRACP、BGP含量,降低PYD/Cr比值,增加骨密度。结论:补土益水汤对去卵巢所致的实验性骨质疏松症具有明显的改善作用。
Objective: To investigate the effect of Bu Tu Yishui Tang on ovariectomized rats with osteoporosis. Methods: The ovariectomized rats were used to induce osteoporosis. The effects of Bu Tu Yishui Decoction on serum calcium and phosphorus, Alkalin phosphatase (ALP), osteocalcin (Bone Glaprotein, BGP, TRACP, Pyridinoline (PYD) / creatinine (Cr) and bone mineral density (BMD) . Results: Bu Tu Yishui Tang can significantly reduce serum ALP, TRACP, BGP content, reduce the PYD / Cr ratio, increase bone mineral density. Conclusion: Bu Tu Yishui Decoction on ovariectomized experimental osteoporosis has a significant improvement.