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产儿呼吸窘迫和透明膜疾患是常见的临床问题。但尽管最近处理方面有所改善(加强新生儿监护和辅助呼吸),死亡率仍高。因为还不能消除早产,故在计划性或先兆早产者有加速宫内胎儿肺成熟的可能。Liggins(1969) 首先观察到用糖代谢皮质激素治疗,加速了羊胎儿肺成熟,其他学者随之给羊胎儿和兔胎儿糖代谢皮质激素引起表面活质迅速出现而改善了早产后肺功能。
Infants with respiratory distress and hyaline membrane disorders are common clinical problems. Despite the recent improvements in handling (strengthening neonatal care and assisted breathing), the mortality rate remains high. Because it can not eliminate premature birth, it is possible in preterm or threatened premature birth to accelerate intrauterine fetal lung maturation. Liggins (1969) first observed that glucocorticoid treatment with glucose accelerated accelerated fetal lung maturation and other scholars subsequently gave rise to rapid surface-metabolisation of glucocorticoids to sheep and rabbit fetuses to improve post-natal lung function.