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壶腹周围癌可来自壶腹部、胰管、远端胆管或十二指肠,临床特征因癌肿不同起源而异。即使行根治性外科手术,大部分壶腹周围腺癌特别是胰导管腺癌病人的预后仍很差,但也有一些长期存活的报告。如果术前能识别可靠的预后因素,就易于选择术式,同时对预后不良的病例作辅助化疗也很有价值。 方法:1960年至1991年胰腺癌或壶腹周围癌患者417例,从中选取经全胰切除或胰十二指肠切除存活者60例分析。根据肿瘤发生部位分成4组,并回顾性分析15个因素。另取36个石蜡标本作肿瘤细胞
The periampullary cancer may come from the ampulla, pancreatic duct, distal bile duct, or duodenum, and the clinical features vary according to the origin of the cancer. Even if radical surgery is performed, the prognosis of most patients with periampullary adenocarcinoma, especially pancreatic ductal adenocarcinoma, is still poor, but there are also reports of long-term survival. If reliable prognostic factors can be identified before surgery, it is easy to choose the procedure. At the same time, adjuvant chemotherapy is also valuable for patients with poor prognosis. Methods: A total of 417 patients with pancreatic cancer or periampullary cancer from 1960 to 1991 were selected and 60 patients with survivors undergoing total pancreatectomy or pancreatoduodenectomy were selected for analysis. According to the location of tumors were divided into 4 groups, and 15 factors were analyzed retrospectively. Another 36 paraffin specimens were used as tumor cells