胰腺损害在形态学上改变十分轻微,但其引起的严重并发症可增加危重病患儿的死亡率。胰腺损害的病因复杂,其发生机制尚不清楚,且国内外尚未作出明确概念界定,缺乏诊断标准和指南。该文结合已有的临床和动物实验研究文献,在小儿急性胰腺炎研究基础上对小儿危重病继发胰腺损害的病因、机制及免疫治疗研究做一综述,以促进这一新领域的研究发展和提高小儿危重病继发胰腺损害的认知水平。 Pancreatic damage morphologically very mild, but the serious complications caused by it can increase the mortality of critically ill children. The etiology of pancreatic damage is complex, its mechanism is not yet clear, and at home and abroad have not yet made a clear definition of the concept, the lack of diagnostic criteria and guidelines. Based on the literature of clinical and animal experimental research, this paper reviews the etiology, mechanism and immunotherapy of pancreatic damage secondary to critical illness in children on the basis of the research of pediatric acute pancreatitis to promote the research development in this new field And to improve the cognitive level of secondary pancreatic damage in critically ill children.