免疫炎性反应在脑缺血后损伤中起重要作用,脑缺血的炎性免疫损伤是一个复杂的病理过程,免疫炎性因子是调节损伤过程免疫反应的关键因子。在炎性反应发生之前,可有细胞因子介导、参与免疫调节和趋化作用,促进白细胞黏附于血管内皮细胞,引起并加重脑缺血损伤,细胞因子产生后进一步诱导黏附分子和趋化因子的表达,促使炎性免疫细胞浸润到损伤组织,炎性免疫细胞及其产生的细胞因子又相互诱导激活,进一步加重组织损伤。 Immune inflammatory reaction plays an important role in the injury of cerebral ischemia. Inflammatory injury of cerebral ischemia is a complicated pathological process. Immune inflammatory factor is the key factor to regulate the immune response during injury. Before the inflammatory reaction occurs, cytokines may be involved in immune regulation and chemotaxis, promote leukocyte adhesion to vascular endothelial cells, cause and aggravate cerebral ischemia injury, cytokine production and further induce adhesion molecules and chemokines The expression of inflammatory cells promote the infiltration of inflammatory cells into injured tissues. Inflammatory immune cells and their cytokines are induced to activate each other, further aggravating the tissue damage.