AIM:To explore the correlation of magnifying endoscopicpatterns and histopathology,Helicobacter pylori (H pylori)infection of the gastric mucosa.METHODS:Gastric mucosal patterns in 140 patients withchronic gastritis were studied using Olympus GIF-Q240Zmagnifying endoscope.Histopathological examination,rapidurease test and Warrthin-Starry staining were taken withbiopsy samples from the magnified sites of stomach.Themagnifying endoscopic patterns were compared withhistopathological results and H pylori detection.RESULTS:The pit patterns of gastric mucosa were classifiedas types A (round spot),B (short rod),C (branched),D(reticular) and E (villus).The detection rate of chronic atrophicgastritis (CAG) by magnifying endoscopy was 94.3 % (33/35),which was significantly higher than that by routine endoscopy(22.9 %,8/35) (P<0.01).The pit patterns of 31 cases ofintestinal metaplasia (IM) appeared as type E in 18 cases(58.1%),type D in 8 cases (25.8 %) and type C in 5 cases(16.1%).Fourteen out of 18 patients (77.8 %) with completetype (type Ⅰ) of IM appeared as type E of pit patterns,whereasonly 4 of 13 (30.8 %) patients with incomplete type (typesⅡ and Ⅲ) of IM appeared as type E (P<0.05).Collectingvenules in the anterior of lower part of gastric corpus weresubgrouped into types R (regular),Ⅰ (irregular) and D(disappeared).H pylori infection was found in 12.2 %(9/74),60 %(9/15) and 84.3 %(43/51) cases in these typesrespectively.H pylori infection rate in type R was significantlylower than that in other two types (P<0.01).CONCLUSION:Magnifying endoscopy may have an obviousvalue in diagnosing chronic atrophic gastritis,intestinalmetaplasia and H pylori infection. AIM: To explore the correlation of magnifying endoscopic patterns and histopathology, Helicobacter pylori (H pylori) infection of the gastric mucosa. METHODS: Gastric mucosal patterns in 140 patients with chronic gastritis were studied using Olympus GIF-Q240 Zmagnifying endoscope. Histopathological examination, rapidurease test and Warrthin Starry staining were taken with the biopsy samples from the magnified sites of the stomach. Magnifying endoscopic patterns were compared with histopathological results and H pylori detection .RESULTS: The pit patterns of gastric mucosa were classifieds types A (round spot), B (short rod), C The detection rate of chronic atrophic gastritis (CAG) by magnifying endoscopy was 94.3% (33/35), which was significantly higher than that by routine endoscopy (22.9%, 8 / 35) (P <0.01) .The pit patterns of 31 cases of intestinal metaplasia (IM) were type E in 18 cases (58.1%), type D in 8 cases .Fourteen out o IM was as type E of the pit patterns, whereasonally 4 of 13 (30.8%) patients with incomplete type (types II and III) of IM was as type E (P <0.05 ). Cllectingvenules in the anterior of lower part of gastric corpus weresubgrouped into types R (regular), I (irregular) and D (disappeared) .H pylori infection was found in 12.2% (9/74), 60% (9/15 ) and 84.3% (43/51) cases in these types separately. H pylori infection rate in type R was significantly lower than those in other two types (P <0.01) .CONCLUSION: Magnifying endoscopy may have an obvious value in diagnosing chronic atrophic gastritis, intestinal metaplasia and H pylori infection.