正常组织中细胞增生与死亡保持平衡 ,细胞增生加快或死亡减慢都可导致肿瘤形成。以往的肿瘤研究主要集中于细胞增生方面 ,自从 1 972年 Kerr等提出了细胞凋亡这一概念后 ,凋亡在肿瘤形成和发展中的作用日益受到重视。许多理化因素如放射、热处理、细胞毒剂、生长因子缺乏等均可 Normal cell proliferation and death to maintain balance, accelerated cell proliferation or death can lead to slow down the formation of tumors. Previous cancer research mainly focused on cell proliferation. Since Kerr et al. Put forward the concept of apoptosis in 1972, the role of apoptosis in tumor formation and development has been paid more and more attention. Many physical and chemical factors such as radiation, heat treatment, cytotoxic agents, lack of growth factors can be