精原干细胞(spermatogonial stem cells,SSCs)具有自我复制和分化的潜能,是成年动物体内能进行遗传信息传递的唯一类型的干细胞,也是维持精子发生这一有序调控过程的起始细胞。精原干细胞在体外的增殖与诱导分化为研究和阐明精子发生机制提供了新的方法和途径。利用体外培养的SSCs,结合移植技术,还可在体外对SSCs的基因组进行操 Spermatogonial stem cells (Spermatogonial stem cells, SSCs) have the potential to self-replicate and differentiate. Spermatogonial stem cells (Spermatogonial stem cells) are the only type of stem cells that can transmit genetic information in adult animals. They are also the starting cells for maintaining the orderly process of spermatogenesis. Proliferation and differentiation of spermatogonial stem cells in vitro provide new methods and ways to study and elucidate the mechanism of spermatogenesis. The use of SSCs cultured in vitro, combined with transplantation, but also in vitro SSCs genome manipulation