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应用组化方法,对36例早孕期人工流产、13例羊膜腔内注射利凡诺中期引产胎盘、28例正常周期育龄妇女黄体,及假孕家免经口给予炔诺酮肟4mg/(kg·d)×3d 后的黄体组织进行3β-羟基甾体脱氢酶(3β-HSD)活性分布测定。发现:早孕期人流胎盘3β-HSD 活性主要存在于合体细胞滋养层中,酶活性从孕7周逐渐增强。利凡诺中期引产胎盘绒毛3β-HSD 活性明显受抑制。正常育龄妇女不同时期卵巢黄体3β-HSD 活性变化与正常月经周期孕酮生理变化一致。假孕家免卵巢黄体细胞3β-HSD活性在药物影响下明显受抑制。本文对酶活性分布、受抑意义及方法、注意事项进行了讨论。
Histopathological examination of 36 cases of early pregnancy induced abortion, 13 cases of intra-amniotic injection of rivanol mid-term induced abortion placenta, 28 cases of normal-cycle women of childbearing age luteal phase, and pseudo-pregnant home-free oral norethisterone oxime 4mg / (kg · 3 days later, the distribution of 3β-hydroxysteroid dehydrogenase (3β-HSD) activity was measured in corpus luteum tissues after 3 days. It was found that the activity of 3β-HSD in the abortion placenta mainly existed in the syncytiotrophoblast during the first trimester, and the enzyme activity increased gradually from the seventh trimester of pregnancy. Rivaroxeto mid-term induction of placental 3β-HSD activity was significantly inhibited. The changes of 3β-HSD activity in corpus luteum of normal women of childbearing age are consistent with the changes of progesterone in normal menstrual cycle. Fetal pregnancy-free ovarian luteal cells 3β-HSD activity was significantly inhibited under the influence of the drug. This article discusses the distribution of enzymes, the significance of inhibition and methods, precautions.