按2×2×2析因设计,以给饲方式对雄性小鼠进行Pb(200ppm),Cd(50ppm),As(50ppm)单独及联合染毒10周。用原子吸收分光光度法测定小鼠肝脏Pb、Cd、As、Zn、Cu、Fe等6种微量元素含量。结果表明:铅、镉和砷联合毒性对小鼠肝脏Pb、Cd、As、Zn、Fe含量的影响与单一毒性影响明显不同,对Cu含量影响则不明显。有害元素之间以及有害元素与必需微量元素之间存在着复杂的相互作用关系。 Male mice were individually and jointly exposed to Pb (200 ppm), Cd (50 ppm), As (50 ppm) for 10 weeks in a 2x2x2 factorial design. Determination of Six Trace Elements Pb, Cd, As, Zn, Cu and Fe in Mouse Liver by Atomic Absorption Spectrophotometry. The results showed that the combined effects of lead, cadmium and arsenic on the contents of Pb, Cd, As, Zn and Fe in the liver of the mice were significantly different from those of the single toxicity, but not obvious for the Cu content. There is a complex interaction between harmful elements and between harmful elements and essential trace elements.