Crohn’s disease is well known to affect any part of thegastrointestinal tract including the oral cavity and anus.Various extraintestinal complications have been reportedin Crohn’s disease,but extraintestinal involvementcharacterized by granulomatous lesions is uncommon.Here,we have reported a case about the involvement ofthe gallbladder in Crohn’s disease.A 33-year-old womanwas diagnosed having panperitonitis due to intestinalperforation and cholecystitis.The patient was moved tothe surgical service for an emergency operation.On theresected specimen,there was a broad longitudinal ulcerat the mesenteric side.The mucosa of the gallbladderwas nodular and granular,and the wall was thickened.The surface epithelium of the gallbladder was partiallyeroded and pyloric gland metaplasia was observedfocally.Rokitansky-Aschoff sinuses were also present.From the lamina propria to the subserosal layer,therewere several well-formed epithelioid cell granulomas,which were the non-caseating sarcoidal type differentfrom the foreign-body and xanthomatous granulomas.Periodic-acid Schiff and acid fast stains revealed noorganism within the granulomas.Lymphoid aggregateswere present throughout the gallbladder wall.Sectionsfrom the resected ileum showed typical features of theCrohn’s disease.When cholecystectomy is performedin a patient with Crohn’s disease,the possibility ofgallbladder involvement should be carefully examined byhistopathological tests. Crohn’s disease is well known to affect any part of the gastrointestinal tract including the oral cavity and anus. Verious extraintestinal complications have been reported in Crohn’s disease, but extraintestinal involvement characterized by granulomatous lesions is uncommon. Here, we have reported about case of the involvement of the gallbladder in Crohn’s disease. A 33-year-old woman was diagnosed with panperitonitis due to intestinal perforation and cholecystitis. The patient was moved tothe surgical service for an emergency operation. On theresected specimen, there was a broad longitudinal ulcerat the mesenteric side. The mucosa of the gallbladderwas nodular and granular, and the wall was thickened. The surface epithelium of the gallbladder was partiallyeroded and pyloric gland metaplasia was observedfocally. Rokitansky-Aschoff sinuses were also present. From the lamina propria to the subserosal layer, therewere several well-formed epithelioid cell granulomas , which were the non-caseating sarcoidal typ e differentfrom the foreign-body and xanthomatous granulomas .Periodic-acid Schiff and acid fast stains revealed noorganism within the granulomas. Lymphoid aggregateswere present throughout the gallbladder wall. Sectionsfrom the resected ileum showed typical features of theCrohn’s disease.When cholecystectomy is performed in a patient with Crohn’s disease, the possibility ofgallbladder involvement should be preferably examined byhistopathological tests.