低浓度的甲硝磺酰咪唑—每毫升1.2—1.8微克加在1—6小时内分离阴道毛滴虫株的培养物中1—3小时后,在电镜下首先见到的超微结构变化为氢小体基质及糖原脱颗粒的改变。6小时后,内质网和高尔基器有退行性变,核和鞭毛的形态保留不变。导言:一种低毒性、高疗效杀滴虫的药物——灭滴灵的合成,实质上推动了治疗阴道毛滴虫的进度,而且,非常有效的硝基咪唑衍生物、nimorazole、甲硝磺酰咪唑和Ornidazole的发现重新引起使用这些硝基咪唑类化合物治疗阴道毛滴虫的兴趣。最近几年间的所研究都集中于灭滴灵对阴道滴虫在生化作用机制和该药在体外引起的 Low concentration of methylsulfonylimidazole - 1.2-1.8 micrograms per milliliter plus isolates of Trichomonas vaginalis cultures in 1 to 6 hours 1-3 hours later, the first ultrastructural change seen under electron microscopy is Hydrogenosome matrix and glycogen degranulation changes. After 6 hours, the endoplasmic reticulum and Golgi apparatus degenerated and the morphology of nucleus and flagella remained unchanged. Introduction: The synthesis of metribuzin, a low-toxicity, highly-effective trichomonad drug, has substantially boosted the progress of Trichomonas vaginalis, and very effective nitroimidazole derivatives, nimorazole, metronidazole The discovery of acyl imidazoles and Ornidazole has revived interest in the treatment of Trichomonas vaginalis using these nitroimidazoles. In recent years, the research has focused on the metronidazole vaginal Trichomonas biochemical mechanism of action and the drug caused in vitro