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本文报道作为生物效应调节剂的PSP对正常动物、负瘤动物和施用化疗药物小鼠的肿瘤免疫学研究结果。口投或腹腔注射PSP(0,5～2.0g/kg×9或200～400rug/Kg×4)能明显提高小鼠对印度墨汁的廓清率(P<0.01),其作用和刺五茄相似;口投1.5g/kg×5剂量的PSP可使小鼠产生IL-2量比生理盐水组高1倍(P<0.01);用含150～800ug/mL PSP的细胞培养液,在Con A存在下,能使牌T淋巴细胞增长1.5～4.0倍;用100～1000ug/mL PSP的细胞培养液培养人血白细胞,其诱生的。和Y干扰素量比对照高2～4倍;PSP用于注射环磷酰胺小鼠,其白细胞数有不同程度的回升,口投组(2.25～4.00g/kg)从40回升到69～74千/mm~3腹腔注射组(200～400mg/kg)从60回升到80～86千/mm~3,PSP还能消除环磷酰胺对IL-2的抑制作用,使注射环磷酰胺小鼠IL-2量从1557cpm上升到2374cpm(P<0.01);PSP对迟发超敏反应(DTH)也有类似效应,它能使被环磷酰胺抑制的DTH反应得到恢复(P<0.05)。 PSP用于负Sarcoma肉瘤小鼠,能使小鼠因负瘤而萎缩的胸腺重量得到增加(P<0.05)并能提高负瘤鼠的抗体和补体C_3含量(P<0.01)。
This article reports the results of a tumor immunological study of PSP as a biological effect modifier on normal animals, oncogenic animals and on chemotherapeutic drugs. Oral injection or intraperitoneal injection of PSP (0,5 ~ 2.0g / kg × 9 or 200 ~ 400rug / Kg × 4) can significantly improve the clearance rate of India ink (P <0.01), and its role and Acanthopanax senticosus similar (P <0.01). In mice treated with 1.5g / kg × 5 PSP, the amount of IL-2 produced in mice was twice as that of the saline group (P <0.01) In the presence, can make the card T lymphocytes increased by 1.5 to 4.0 times; with 100 ~ 1000ug / ml PSP culture of human blood cells white blood cells, its induced. And Y interferon 2 ~ 4 times higher than the control; PSP for injection of cyclophosphamide mice, the number of white blood cells rose to varying degrees, the mouth cast group (2.25 ~ 4.00g / kg) rose from 40 to 69 ~ 74 Kg / mm ~ 3 intraperitoneal injection group (200 ~ 400mg / kg) rose from 60 to 80 ~ 86 1000 / mm ~ 3, PSP can also eliminate the inhibitory effect of cyclophosphamide on IL-2, cyclophosphamide in mice injected The level of IL-2 increased from 1557cpm to 2374cpm (P <0.01). PSP also had a similar effect on DTH, which restored the DTH response inhibited by cyclophosphamide (P <0.05). PSP used in negative Sarcoma sarcoma mice increased the weight of thymus in mice (P <0.05) and increased the antibody and complement C_3 in tumor - bearing mice (P <0.01).