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本研究系从体外试验中选择了溶解速度最快和最慢的二个不同厂的片剂与滴丸进行体内有效性试验。采用竞争性蛋白结合法测定血中强的松龙浓度。经两室模型(口服)的数学处理和电子计算机运算结果表明在两种片剂之间有显著差异。滴丸与片剂(A)是等效的,但倍效于片剂(C)。体外一体内存在相关关系。α与β值相差较大,A值也大,速度常数K_1、K_2、K_E均为正值,可以认为强的松龙属两室模型药物。
In this study, in vitro experiments were selected in the dissolution of the fastest and slowest two different factories tablets and pills for in vivo effectiveness of the test. Determination of prednisolone in blood by competitive protein binding assay. The mathematical treatment and computational results of the two-compartment model (oral) showed significant differences between the two tablets. Drop pills are equivalent to Tablets (A) but are effective at Tablets (C). In vitro and in vivo there is a correlation. α and β values vary greatly, A value is also large, the speed constants K_1, K_2, K_E are positive, it can be considered prednisolone is a two-compartment model drug.