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目的探讨结节性甲状腺肿并存甲状腺癌的诊断,为结节性甲状腺肿并存甲状腺癌的治疗提供理论依据。方法182例结节性甲状腺肿患者,根据患者病症分为对照组(169例)和观察组(13例)。对照组患者为单纯的结节性甲状腺肿,观察组患者为结节性甲状腺肿合并甲状腺癌。分析两组患者甲状腺局部情况,比较两组患者甲状腺中甲状腺抗体的表达情况。结果确诊有甲状腺癌的患者有13例,发生率为7.14%;观察组患者结节数目明显优于对照组,差异具有统计学意义(χ~2=13.758,P<0.05),观察组患者钙化情况明显优于对照组,差异具有统计学意义(χ~2=17.274,P<0.05);观察组患者的甲状腺球蛋白抗体中的mRNA和蛋白水平与对照组比较差异有统计学意义(P<0.05),观察组患者的甲状腺微粒抗体中的mRNA和蛋白水平与对照组比较差异无统计学意义(P>0.05)。结论根据甲状腺球蛋白抗体的水平情况筛选结节性甲状腺肿并存甲状腺癌患者,确定患者的病症后,进行相关的手术进行治疗。
Objective To investigate the diagnosis of nodular goiter complicated with thyroid cancer and to provide a theoretical basis for the treatment of nodular goiter complicated with thyroid cancer. Methods A total of 182 patients with nodular goiter were divided into control group (n = 169) and observation group (n = 13) according to the patient’s condition. Patients in the control group were simple nodular goiter. Patients in the observation group were nodular goiter with thyroid cancer. Thyroid gland status was analyzed in both groups. Thyroid antibody expression was compared between the two groups. Results Thirteen patients were diagnosed as having thyroid cancer, the incidence was 7.14%. The number of nodules in the observation group was significantly better than that in the control group (χ ~ 2 = 13.758, P <0.05). The calcification (Χ ~ 2 = 17.274, P <0.05). The mRNA and protein levels of thyroglobulin antibody in the observation group were significantly different from those in the control group (P <0.01), and the difference was statistically significant 0.05). There was no significant difference between the observation group and the control group in the mRNA and protein levels of thyroid antibody (P> 0.05). Conclusion According to the level of thyroglobulin antibody screening for patients with nodular goiter with thyroid cancer, determine the patient’s illness, the relevant surgery for treatment.