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目的:探讨舒芬太尼自控静脉镇痛对肺癌切除术后患者血流动力学及免疫功能的影响。方法:选择2009年2月-2014年2月在我院行肺叶切除术的非小细胞肺癌(NSCLC)患者110例,依据随机数字表法将全部患者分为对照组和观察组,每组55例。术后观察组患者接受舒芬太尼自控静脉镇痛,对照组接受芬太尼自控静脉镇痛,观察两组患者血液动力学指标和免疫功能指标的差异。结果:镇痛1 d后,观察组全血粘度、全血还原粘度、红细胞聚集指数(RAI)和毛细血管血浆粘度均显著低于对照组(均P<0.05),CD4+T细胞、IL-2含量观察组显著高于对照组(P<0.05),CD8+T细胞、IL-6、IL-10含量观察组均显著低于对照组(均P<0.05)。结论:肺癌根治术后采用舒芬太尼自控静脉镇痛可显著调节患者血流动力学指标,改善机体免疫功能,可推广临床实践。
Objective: To investigate the effects of sufentanil-controlled intravenous analgesia on hemodynamics and immune function in patients with lung cancer after resection. Methods: A total of 110 patients with non-small cell lung cancer (NSCLC) who underwent lobectomy in our hospital from February 2009 to February 2014 were enrolled. All patients were divided into control group and observation group according to random number table example. Patients in the postoperative observation group received sufentanil-controlled intravenous analgesia, while those in the control group received fentanyl-controlled intravenous analgesia. The difference in hemodynamic and immune function between the two groups was observed. Results: The whole blood viscosity, erythrocyte aggregation index (RAI) and capillary plasma viscosity of the observation group were significantly lower than those of the control group (all P <0.05) after 1 day of analgesia. The levels of CD4 + T cells and IL- (P <0.05). The contents of CD8 + T cells, IL-6 and IL-10 in the observation group were significantly lower than those in the control group (all P <0.05). CONCLUSIONS: Sufentanil-controlled intravenous analgesia after radical operation of lung cancer can significantly regulate the hemodynamic parameters, improve the immune function and promote the clinical practice.