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我们于1982年对45例住院的流行性出血热患者作了观察,包括血液流变学测定(43例),血小板功能测定(45例),血小板、红细胞涂片应用免疫荧光法检测免疫复合物(血小板21例、红细胞12例),补体系统激活、旁路和经典途径测定(45例),皮肤瘀点活检应用免疫荧光法检测免疫复合物(3例)。观察结果:1.在发热期早期全血粘滞度即明显增高,但血浆粘滞度正常。显微镜下观察红细胞表面有免疫复合物存在,且红细胞有聚集现象。2.血小板聚集和释放功能均有明显下降,并与病情严重程度相一致。
We observed 45 hospitalized patients with epidemic hemorrhagic fever in 1982, including hemorheology (43 cases), platelet function test (45 cases), platelet, and erythrocyte smears using immunofluorescence to detect immune complexes (21 cases of platelet, 12 cases of erythrocytes), complement system activation, bypasses and classical pathway determination (45 cases), skin petechia biopsy by immunofluorescence assay immune complexes (3 cases). Observations: 1. In the early heat of whole blood viscosity was significantly increased, but plasma viscosity was normal. Under the microscope, the immune complexes were observed on the surface of erythrocytes, and erythrocytes were aggregated. 2. Platelet aggregation and release were significantly decreased, and consistent with the severity of the disease.