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目的:观察两种常用一线根除幽门螺杆菌(H.pylori)三联方案在本地区(成都市)的疗效。方法:纳入70例诊断为消化性溃疡、慢性糜烂性胃炎、慢性萎缩性胃炎伴H.pylori感染的患者。随机分为A、B两组。A组采用埃索美拉唑(E)20 mg bid+克拉霉素(C)500 mg bid+甲硝唑(M)400 mg bid,B组采用E 20 mg bid+C 500 mg bid+阿莫西林(A)1.0g bid治疗,疗程7天。H.pylori根除失败者以1周四联方案:E 20 mg bid+胶体次枸櫞酸铋(B)220 mg bid+呋喃唑酮100 mg bid+A1.0g bid治疗,观察疗效。结果:64例完成实验。三联方案H.pylori根除率:A组62.5%,B组84.4%,有显著差异(P<0.05)。二线四联方案根除率94.1%。结论:ECA方案H.pylori根除率明显高于ECM方案,可能更适合于本地区根除H.pylori的一线治疗,EBFA方案作为二线治疗具有较高疗效。
Objective: To observe the efficacy of two common first-line eradication of H. pylori triple regimen in this region (Chengdu). Methods: A total of 70 patients diagnosed as peptic ulcer, chronic erosive gastritis and chronic atrophic gastritis with H. pylori infection were enrolled. Randomly divided into A, B two groups. Group A received 20 mg bid of esomeprazole (E), 500 mg bid of clarithromycin (C) and 400 mg bid of metronidazole (M), while those in the group B received E 20 mg bid + C 500 mg bid plus amoxicillin (A ) 1.0g bid treatment, treatment for 7 days. Efficacy of H.pylori eradication was evaluated by a four-week regimen: E 20 mg bid + colloidal bismuth subcitrate (B) 220 mg bid + furazolidone 100 mg bid + A1.0 g bid. Results: 64 cases completed the experiment. The triple regimen H.pylori eradication rate: 62.5% in group A, 84.4% in group B, there was a significant difference (P <0.05). Second-tier four programs eradication rate of 94.1%. Conclusions: The eradication rate of H.pylori in ECA regimen is significantly higher than that in ECM regimen, which may be more suitable for the first-line treatment of H.pylori eradication in this region. EBFA regimen has higher efficacy as second-line treatment.