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利用PCR-SSCP银染技术对30例鼻咽癌患者的Smad2/4基因的所有外显子进行突变分析,以探讨Smad2/4基因与鼻咽癌发病的可能相互关系。结果在所有病例的所有外显子上没有发现任何类型的突变。Smad2/4基因可能不是鼻咽癌的易感基因,TGF-β/Smad2/4信号通路可能不参与鼻咽癌的发病。
All exons of Smad2 / 4 gene in 30 patients with nasopharyngeal carcinoma were analyzed by PCR-SSCP silver staining to explore the possible relationship between Smad2 / 4 gene and nasopharyngeal carcinoma. As a result, no type of mutation was found in all exons in all cases. Smad2 / 4 gene may not be a susceptibility gene of nasopharyngeal carcinoma, TGF-β / Smad2 / 4 signaling pathway may not be involved in the pathogenesis of nasopharyngeal carcinoma.