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1988年10月至1990年11月应用每天静滴 VCR 0.5～1.0mg,ADM10～20mg 和 DXM20mg。连续4天为1疗程的 VAD 方案治疗难治性晚期多发性骨髓瘤(MM)13例。每疗程后休息7～21天,重复治疗至取得缓解为止。连续观察治疗13例结果获显著效果者11例(84.6%),有效2例(15.4%),总有效率100%。取得缓解的疗程为2～6(平均3.6)疗程。该方案疗效出现快,对不适宜用烷化剂治疗的伴有骨髓瘤性肾病、高氮质血症和高钙血症者适用。着重讨论了在应用该方案治程中血像变化的规律及其对指导临床治疗的意义。
October 1988 to November 1990 application daily intravenous VCR 0.5 ~ 1.0mg, ADM 10 ~ 20mg and DXM20mg. Thirteen consecutive patients were treated with VAD regimen for refractory advanced multiple myeloma (MM) for 4 consecutive days. Rest for 7 to 21 days after each course of treatment until repeated treatment is achieved. Continuous observation and treatment of 13 cases were significantly effective in 11 cases (84.6%), effective in 2 cases (15.4%), the total efficiency of 100%. The course of treatment was 2 to 6 (average 3.6) course of treatment. The program efficacy appears fast, not suitable for treatment with alkylating agents associated with myelogenous nephropathy, high azotemia and hypercalcemia who apply. It focuses on the rule of blood changes in the course of applying the program and its significance for guiding the clinical treatment.