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【目的】探讨原发性甲状腺功能亢进症（甲亢）患者血尿酸（UA）与甲状腺功能水平的相关性。【方法】收集原发性甲亢患者61例，按照血 UA 水平（男性＞420μmol／L ，女性＞360μmol／L ）分为高尿酸血症（ HUA）组、正常尿酸血症（ NUA）组，另外收集同期年龄和性别匹配的健康体检人群作为健康对照组，检测并比较三组甲状腺功能指标[游离三碘甲腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺激素（TSH ）水平]、空腹血糖（FBS）、肾功能指标[尿素氮（BUN）、肌酐（Cr）、UA ]；肝功能[丙氨酸基转移酶（ALT ）和天冬氨酸氨基转移酶（AST ）]、血脂[三酰甘油（TG）、胆固醇（TC）、高密度脂蛋白（HDL‐C）、低密度脂蛋白（LDL‐C）]，分析 UA 与甲状腺功能水平的相关性。【结果】NUA 组 FT3、FT4均明显高于对照组（P ＜0．01），而 TC 、HDL‐C 、LDL‐C 、TSH 均明显低于对照组（P ＜0．01），但两组 FBS 、AST 、TG 、BUN 、Cr 、UA 比较差异无统计学意义（P ＞0．05）。与 NUA 组比较，HUA 组 BUN 、UA 、Cr 、FT3、FT4明显升高（P ＜0．05），TSH 水平明显下降，其差异均有统计学意义（P ＜0．05）；而两组 FBS 、ALT 、AST 、TG 、TC 、HDL‐C 、LDL‐C 比较差异无统计学意义（P ＞0．05）。 UA 与 FT3、FT4呈正相关（P ＜0．05），与 TSH 呈负相关（P ＜0．05），血清 Cr 与 FT3、FT4呈负相关（P ＜0．05）。【结论】原发性甲亢患者易合并血 UA 升高，血 UA 水平与患者的高甲状腺激素水平密切相关。“,”Objective]To investigate the correlation between serum uric acid (UA) and thyroid function in pa‐tients with primary hyperthyroidism .[Methods]Sixty‐one cases of primary hyperthyroidism were collected ,and were divided into hyperuricemia (HUA) group and normal uric acid (NUA) group according to the blood UA level (male > 420 mol / L ,female > 360μmol/L) .In addition ,healthy physical examination population of the same age and gender matched were collected as a healthy control group .The following were detected and compared in the three groups including the thyroid function indicators :free three iodine thyroid gland (FT3) ,free thyroid hor‐mone (FT4) ,thyroid stimulating hormone (TSH) level) ,Fasting blood glucose (FBS) ;the renal function :blood urea nitrogen (BUN) ,creatinine (Cr) ,UA ;the liver function :alanine aminotransferase (ALT ) and aspartate aminotransferase (AST ) ; the blood lipids : three glycerol (TG ) ,cholesterol (TC ) , high density lipoprotein (HDL‐C) ,low density lipoprotein (LDL‐C) .The correlation between UA and thyroid function was analyzed .[Re‐sults]FT3 and FT4 in the NUA group were significantly higher than the control group ( P < 0 .01) ,while the TC , HDL‐C ,LDL‐C ,TSH were significantly lower than the control group ( P 0 .05) .Compared with NUA group , BUN ,UA ,Cr ,FT3 ,FT4 of the HUA group were significantly increased ( P < 0 .05) ,TSH level was signifi‐cantly decreased ,and the difference was statistically significant ( P 0 .05) .UA was positively correlated with FT3 and FT4 ( P < 0 .05) ,and was negatively correlated with TSH ( P < 0 .05) ,Serum Cr was negatively corre‐lated with FT3 and FT4 ( P < 0 .05) .[Conclusion]Patients with primary hyperthyroidism can be easily combined with blood UA elevation .The level of serum UA is closely related to the level of thyroid hormone of patients .