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我们遇到一例因复用利福平引起肾功能衰竭的病人。患者女性,69岁。主诉恶心、少尿。于1977年7月,因肺结核复发曾在某院治疗。始用卡那霉素、异烟肼、利福平等抗结核药。自翌年7月起改为利福平,2次/周、以间歇法服用,给药后患者出现低热,至12月停药。1980年1月患者再次应用利福平,450mg/日,至服药第4日感到胸闷,有呕吐、畏寒、高热,继之少尿,尿呈暗红色。间接胆红质0.8mg/dl,
We encountered a case of renal failure due to re-use of rifampin patients. Patient female, 69 years old. Chief complaint nausea, oliguria. In 1977 July, because of tuberculosis recurrence in a hospital. Start with kanamycin, isoniazid, rifampin and other anti-TB drugs. Since July the following year changed to rifampicin, 2 times / week, taking intermittent treatment, patients with hypothermia after drug administration, to December withdrawal. 1980 January again patients with rifampin, 450mg / day, to the fourth day of medication felt chest tightness, vomiting, chills, fever, followed by oliguria, urine dark red. Indirect chromaffin 0.8mg / dl,