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目的 研究呋喃唑酮 (F)或甲硝唑 (M)联用阿莫西林 (A)及枸橼酸铋钾 (C) 1周疗法治疗飞行员幽门螺杆菌 (Hp)阳性消化性溃疡的疗效。方法 60例飞行员经胃镜证实患有直径≥ 3 mm的活动期消化性溃疡 ,随机分为治疗组和对照组 ,每组各 3 0例。治疗组 (CAF )给予呋喃唑酮 0 .1g,3 /日 ;联用枸橼酸铋钾 0 .2 2 g,2 /日 ;阿莫西林 1g,3 /日。对照组 (MAF)给予甲硝唑 0 .4g,3 /日 ,联用枸橼酸铋钾 0 .2 2 g,2 /日 ;阿莫西林 1g,3 /日。疗程均为7日。结果 溃疡愈合率 ,HP根除率治疗组分别为 93 %、93 % ,而对照组分别为 76%、70 % ,两组比较差异有显著性。治疗 1日、3日、7日缓解腹痛显效率治疗组分别为 63 %、90 %、97% ,对照组分别为 5 3 %、69%、76% ,两组比较差异有显著性。两组均无严重不良反应 ,患者依从性较好。结论 CAF疗法较 MAF疗法疗效好 ,不良反应少 ,依从性好 ,是更理想的消化性溃疡治疗方案
Objective To investigate the efficacy of furazolidone (F) or metronidazole (M) in combination with amoxicillin (A) and bismuth potassium citrate (C) for one week in the treatment of positive Helicobacter pylori (Hp) -positive peptic ulcer in pilots. Methods Sixty pilots confirmed active gastroduodenal ulcer with diameter ≥ 3 mm by gastroscope and were randomly divided into treatment group and control group with 30 cases in each group. The treatment group (CAF) was given Furazolidone 0. 1g, 3 / day; combined with bismuth potassium citrate 0.22g, 2 / day; amoxicillin 1g, 3 / day. The control group (MAF) was given metronidazole 0.4g, 3 / day, combined with bismuth potassium citrate 0.22g, 2 / day; amoxicillin 1g, 3 / day. Treatment are 7 days. Results The ulcer healing rate and HP eradication rate were 93% and 93% in the treatment group, while those in the control group were 76% and 70%, respectively. There was significant difference between the two groups. The effective rate of relieving abdominal pain was 63%, 90% and 97% respectively on the 1st, 3rd and 7th day in the treatment group, while the control group was 53%, 69% and 76% respectively. There was significant difference between the two groups. No serious adverse reactions in both groups, patients with better compliance. Conclusions CAF therapy is more effective than MAF therapy with less adverse reactions and good compliance, which is a better treatment plan for peptic ulcer