用正常人低密度脂蛋白（ＬＤＬ）在体外与葡萄糖一起孵育使ＬＤＬ发生非酶性糖基化，并观察了糖基化ＬＤＬ（ＮＥＧ－ＬＤＬ）果糖胺（ＦＡ）的含量，电泳迁移率及对血小板聚集的影响。结果发现ＬＤＬ中ＦＡ含量随ＬＤＬ与葡萄糖孵育时间延长而增高，并与培养液中葡萄糖浓度呈正相关。ＬＤＬ中ＦＡ含量与ＬＤＬ电泳迁移率呈正相关。ＮＥＧ－ＬＤＬ中ＦＡ含量越高，有使血小板对肾上腺素越敏感，聚集率越高的趋势。本结果提示ＬＤＬ中ＦＡ含量反映了ＬＤＬ糖基化程度。ＬＤＬ发生糖基化后其物理、化学及生物学特性均发生了改变。 LDL was incubated with glucose in vitro to induce non-enzymatic glycosylation of LDL, and the content of glycosylated LDL (NEG-LDL) fructosamine (FA), electrophoretic mobility and Impact on platelet aggregation. The results showed that the content of FA in LDL increased with the prolongation of LDL and glucose incubation time, and was positively correlated with the glucose concentration in culture medium. LDL FA content and LDL electrophoretic mobility was positively correlated. The higher the content of FA in NEG-LDL, the more sensitive the platelets to epinephrine and the higher the aggregation rate. The results suggest that the level of FA in LDL reflects the degree of LDL glycosylation. The glycosylation of LDL has changed its physical, chemical and biological properties.