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目的探讨fascin在乳腺浸润性导管癌组织中的表达及其临床病理意义。方法采用免疫组化法检测88例乳腺浸润性导管癌组织中fascin的表达情况,分析其与ER、PR和HER2表达及乳腺浸润性导管癌预后的关系。结果乳腺正常导管上皮和浸润性导管癌组织中fascin的阳性率分别为9.1%(1/11)和48.86%(43/88),乳腺浸润性导管癌组织中的阳性率明显高于乳腺正常导管上皮组织(P<0.05),其阳性率与腋淋巴结转移状况、组织学分级和TNM分期呈正相关(P<0.05),并且在ER和PR阴性组中明显高于阳性组(均P<0.05),而在HER2阳性组中明显高于阴性组(P<0.05)。fascin阳性表达患者的术后生存时间明显短于阴性患者(P<0.05)。结论fascin可能在乳腺浸润性导管癌的浸润转移过程中发挥重要作用,其阳性表达提示预后较差。
Objective To investigate the expression of fascin in breast invasive ductal carcinoma and its clinicopathological significance. Methods Immunohistochemistry was used to detect the expression of fascin in 88 invasive ductal carcinomas of the breast. The relationship between the expression of ER, PR, HER2 and the prognosis of breast invasive ductal carcinoma was analyzed. Results The positive rates of fascin in normal ductal epithelium and infiltrating ductal carcinoma tissues were 9.1% (1/11) and 48.86% (43/88), respectively. The positive rate of fascin in breast invasive ductal carcinoma was significantly higher than that in normal breast duct (P <0.05). The positive rate was positively correlated with the status of axillary lymph node metastasis, histological grade and TNM stage (P <0.05), and significantly higher in ER and PR negative group than in positive group (all P <0.05) , But higher in HER2 positive group than in negative group (P <0.05). The survival time of patients with fascin positive expression was significantly shorter than that of negative patients (P <0.05). Conclusion Fascin may play an important role in the invasion and metastasis of invasive ductal carcinoma of breast. The positive expression of fascin suggests that the prognosis is poor.