目前普遍认为大疱性类天疱疮(BP)属于体液性自家免疫性疾病,损害周围的皮肤存在抗基底膜(BMZ)抗体,并与发病有关.血清中有在体外能固定补体的游离抗BMZ抗体,但与病情关系不大.在IgG沉着物中经常发现C_3,因此支持抗体与抗原反应而被固定在局部组织的设想.经常查到C_(1q)及(或)C_4皮肤沉着提示传统途径在局部活化.本文 Currently bullous pemphigus (BP) is generally considered to be a humoral autoimmune disease that damages the presence of anti-basal membrane (BMZ) antibodies in the surrounding skin and is associated with the onset of disease. There is free serum that can fix complement in vitro BMZ antibody, but has little to do with the disease in the IgG deposits are often found C_3, thus supporting the antibody and antigen reaction was fixed in the local tissue design often found C_ (1q) and (or) C_4 skin pigmentation prompted the traditional Pathways are activated locally