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Magnius 等首先在乙型肝炎 e 抗原(HBeAg)和抗-HBe 琼脂扩散板上发现一条明显的和二条隐约的沉淀线。其后证实明显的沉淀线为 HBeHg 和抗-HBe所致;而二条隐约的沉淀线则是由其亚型系统造成(HBeAg/1 抗-HBe/1和 HBeAg/2抗-HBe/2)。后来的研究表明 HBeAg 的亚型在抗原上也和乙型肝炎病毒(HBV)核心颗粒相关。为了解 HBV 感染期间 HBeAg 亚型的病毒学意义,作者将 HHeAg 阳性的血清,用琼脂扩散法检测 HBeAg 亚型。根据 HBeAg 亚型将病人分为3组,每组20例。第1组血清 HBeAg/1和 HBeAg/2均为阳性;第2组则仅 HBeAg/1阳性;第3组 HBeAg 亚
Magnius and others first found a clear and diminished sediment line on the HBeAg and anti-HBe agar diffusion plates. Subsequent confirmation of clear precipitation lines was due to HBeHg and anti-HBe, while two obscure precipitation lines were caused by their subtype system (HBeAg / 1 anti-HBe / 1 and HBeAg / 2 anti-HBe / 2). Subsequent studies have shown that subtypes of HBeAg are also antigenically related to hepatitis B virus (HBV) core particles. To understand the virological significance of HBeAg subtypes during HBV infection, the authors tested HHeAg-positive sera for HBeAg subtypes by agar diffusion. According to the HBeAg subtype, the patients were divided into 3 groups, 20 cases in each group. Serum HBeAg / 1 and HBeAg / 2 in group 1 were positive; group 2 only HBeAg / 1 was positive; group 3 HBeAg /