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自1919年发现维生素D(简称VD)以来,VD主要用于佝偻病的治疗。由于VD的活性形式是在一定器官(肾)内形成,经血液作用于一定的靶细胞(小肠、骨、肾),引起一定的生物学效应,与激素的定义相符。有人认为人体皮肤能产生VD,加之VD不是机体内任何一种酶的辅酶或辅基,可把VD从维生素类中分划出来,称作VD-内分泌系统,属一种内分泌激素。 1VD的药理 1.1 VD的代谢和调节 VD有两种:一种是植物性麦角醇经光照生成的VD_2,另一种是人皮肤中的7-脱氢胆固醇在紫外线催化下生成VD_3。动物性食物,尤其是鱼肝油中含VD_3。
Since 1919 found that vitamin D (VD for short), VD is mainly used for the treatment of rickets. As the active form of VD is formed in certain organs (kidneys), certain biological effects are caused by blood acting on certain target cells (small intestine, bone and kidney), which is consistent with the definition of hormone. Some people think that human skin can produce VD, combined with VD is not the body of any enzyme coenzyme or prosthetic group, the VD can be divided from the vitamins, called VD - endocrine system, is an endocrine hormone. 1VD 1.1 pharmacological 1.1 VD metabolism and regulation of VD there are two: one is vegetative ergot alcohol VD2, the other is the human skin 7-dehydrocholesterol under the ultraviolet light to generate VD_3. Animal food, especially cod liver oil containing VD_3.