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目的探讨利用卡氮芥(BCNU)结合Ommeya贮药囊对提高脑胶质瘤患者的治疗效果。方法31例脑胶质瘤患者术后接受皮下埋置Ommaya囊,通过向Ommaya囊内注射卡氮芥从而达到向瘤腔内局部间质化治疗的效果。结果化疗后联合治疗组均未发生严重并发症。随访1~3年后,1例死亡,3例复发,1例可疑复发,其余26例MRI提示胶质瘤术后改变,无复发现象。相比单纯化疗组,患者的生存时间明显延长,且Karnofsky评分明显改善。结论实验结果初步表明Ommaya囊结合卡氮芥的联合应用是临床治疗脑胶质瘤一种可供选择的安全有效的方法。
Objective To investigate the effect of BCNU combined with Ommeya sachet on the treatment of patients with glioma. Methods Thirty-one patients with glioma underwent subcutaneous embedding of the Ommaya capsule after intracameral injection of Carmustine into Ommaya in order to achieve the effect of local interstitial chemotherapy. Results After chemotherapy, no serious complications occurred in the combined treatment group. After 1 to 3 years of follow-up, 1 patient died, 3 patients relapsed, and 1 patient developed suspicious relapse. The other 26 MRIs showed that the glioma was changed after operation, and no recurrence was found. Compared with the chemotherapy alone group, patients’ survival time was significantly longer, and Karnofsky score improved significantly. Conclusion The preliminary results of the experiment show that the combination of Ommaya capsule and carmustine is an effective and safe method for clinical treatment of glioma.