霉酚酸酯是一种选择性作用于淋巴细胞的新型免疫抑制剂。它非竞争性、可逆性地抑制次黄嘌呤核苷酸脱氢酶活性 ,抑制T、B淋巴细胞的增殖和B淋巴细胞的抗体形成 ,并干扰粘附分子的糖基化。在狼疮性肾炎动物模型中 ,MMF显著改善蛋白尿、降低抗体水平、减轻病理损害、延长动物生存时间。在狼疮性肾炎患者中 ,MMF的运用也取得了令人满意的结果。 Mycophenolate mofetil is a novel immunosuppressant that selectively acts on lymphocytes. It is noncompetitive, reversibly inhibits inosine monophosphate dehydrogenase activity, inhibits T, B lymphocyte proliferation and B lymphocyte antibody formation, and interferes with the adhesion molecule’s glycosylation. In animal models of lupus nephritis, MMF significantly improves proteinuria, reduces antibody levels, reduces pathological damage, and prolongs animal survival. In patients with lupus nephritis, the use of MMF also achieved satisfactory results.