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用核素心室造影法测定硝苯吡啶对11例无症状性慢性主动脉瓣关闭不全患者静息和运动时左心室功能的作用。经3月硝苯吡啶治疗后,静息和运动时收缩压降低。运动时,左心室舒张末期容量不变,但收缩末期容量减低,射血分数增高。本研究表明,慢性硝苯吡啶治疗能减低慢性主动脉瓣关闭不全患者左心室收缩负荷,使左心室功能对运动的反应改善。
Radionuclide ventriculography was used to determine the effect of nifedipine on left ventricular function at rest and during exercise in 11 asymptomatic patients with chronic aortic regurgitation. After nifedipine treatment in March, resting and exercise systolic blood pressure decreased. Exercise, left ventricular end-diastolic volume unchanged, but reduced end-systolic volume, ejection fraction increased. This study shows that chronic nifedipine treatment can reduce left atrial systolic load in patients with chronic aortic regurgitation, so that left ventricular function improved response to exercise.