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目的:分析肝细胞癌MR信号与组织学、核DNA含量的相关性。材料和方法:用0.35T磁共振仪检查41例肝细胞癌(HCC),均经手术、病理证实。将磁共振信号改变分为稍低/稍高信号、低/高信号及信号不均三组,组织学上分为梁索优势型、假腺管优势型及实质优势型;用图像分析仪测每例癌细胞核DNA含量,计算DNA指数(DI)及倍型。结果:稍低/稍高信号组,以梁索优势型为多,占95.6%,平均DI为2.39;低/高信号组,以实质优势型为多,占68%,平均DI为3.78,二者之间有统计学差异(P<0.01)。结论:HCC的磁共振信号改变一定程度上反映了不同的组织学类型及DNA含量的高低。
Objective: To analyze the correlation between MR signal, histology and nuclear DNA content in hepatocellular carcinoma. Materials and Methods: Forty-one cases of hepatocellular carcinoma (HCC) were examined with a 0.35T magnetic resonance apparatus and confirmed by surgery and pathology. The magnetic resonance signals were divided into three groups: slightly lower/slightly higher signal, lower/higher signal, and uneven signal. Histologically, it was divided into beam-dominant type, false-dominant tube type, and dominant advantage type; it was measured with an image analyzer. The nuclear DNA content of each cancer cell was calculated and the DNA index (DI) and haplotype were calculated. RESULTS: In the slightly lower/slightly high signal group, the preponderance of girder was more, accounting for 95.6%, and the average DI was 2.39; the low/high signal group was more substantial, accounting for 68%, and the average DI was 3 There was a statistically significant difference between the two groups (P<0.01). CONCLUSIONS: The changes in HCC magnetic resonance signals reflect different histological types and levels of DNA content to some extent.