本项研究从仿红细胞出发，将增加双分子脂膜亲水性的ＰＥＧＰＥ（聚乙二醇与磷脂酰乙醇胺的衍生物）及增加双分子脂膜硬度的ＳＭ（神经鞘磷脂）掺入脂质体，比较其在体外稳定性、体内分布及清除半衰期。结果证明该类脂质体稳定性提高，体内被肝、脾清除减少，血循环中半衰期显著延长。本研究为脂质体载药至非网状内皮系统的靶向给药打下基础。 This study starting from the imitation of red blood cells, will increase the hydrophilic bimolecular lipid PEG PE (polyethylene glycol and phosphatidylethanolamine derivatives) and increase the bilem lipid membrane hardness SM (sphingomyelin) incorporation Liposomes were compared in vitro stability, in vivo distribution and elimination half-life. The results show that the stability of liposomes increased, the body was reduced by the liver and spleen, blood circulation half-life was significantly prolonged. This study lays the foundation for the targeted delivery of liposomes to non-reticuloendothelial system.