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目的 探讨TNF-α基因在肺癌组织中的表达及其临床意义。方法 应用免疫组化SP法检测40例肺癌组织中肿瘤坏死因子(Tumor necrosis factor,TNF-α)的表达，并与癌旁正常肺组织对照。结果 TNF-α阳性表达主要分布于癌细胞胞浆中，阳性率为47..5%(19/40)，细胞核内无阳性表达；癌旁正常肺组织内无阳性表达(P＜0..05)。结论 TNF-α与肺癌的发生、发展有着密切关系。
Objective To investigate the expression of TNF-α gene in lung cancer and its clinical significance. Methods Immunohistochemical SP method was used to detect the expression of Tumor necrosis factor (TNF-α) in 40 cases of lung cancer, and it was compared with normal lung tissue adjacent to the tumor. Results The positive expression of TNF-α mainly distributed in the cytoplasm of cancer cells, with a positive rate of 47..5% (19/40). There was no positive expression in the nucleus; there was no positive expression in the adjacent normal lung tissue (P<0.. 05). Conclusion TNF-α is closely related to the occurrence and development of lung cancer.