随着微泡作为一种新型基因载体可行性研究的逐步深入和超声破坏微泡增强基因转染机制认识的不断提高,超声与微泡在肿瘤基因治疗领域中的应用日益广泛。基因治疗在肿瘤领域的成功应用为卵巢癌基因治疗奠定了基础。超声靶向破坏携基因微泡定位释放技术是一种新型的基因转染技术,其治疗的靶向性及无创性已得到证实。现就该技术在卵巢癌治疗方面的研究进展作一综述。 With the further research on the feasibility of microbubbles as a novel gene carrier and the increasing understanding of the mechanism of ultrasound-mediated microbubble-enhanced gene transfection, the applications of ultrasound and microbubbles in the field of oncology gene therapy are increasingly widespread. The successful application of gene therapy in the field of cancer laid the foundation for gene therapy of ovarian cancer. Targeted and noninvasive therapy has been demonstrated by ultrasound-targeted disruption targeting gene microbubble localization and release technology, a novel gene transfection technique. Now the technology in the treatment of ovarian cancer are reviewed.