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新喋呤(Neopterin, Ne)分子量253,为来自GTP(谷氨酰转肽酶)的代谢产物。体内的Ne一般认为主要是伴随着免疫靶细胞中T细胞活化而释放IFN-γ(干扰素-γ)使单核细胞活化后由单核细胞产生。本文报告的是作者对脑膜炎患儿脑脊液(CSF)中Ne浓度的测定,用以鉴别细菌性与无菌性脑膜炎。对象和方法:CSF与血液发现致病菌的细菌性脑膜炎患儿10例(0～6岁);CSF细菌培养阴性及临床所见诊断为无菌性脑膜炎的患儿9例(其中包括流行性腮腺炎4例,0～7岁)。对照组为可疑脑膜炎而CSF无异常所见的尿路感染等非中枢性疾病的患者及癲痫等各种非炎症性疾病的患儿共45例。脑膜炎患儿在入院时及病情变化的过程中,多次测定CSF中Ne浓度并就其峰值进行比较。同时在CSF测定的同一天,对9例细菌性脑膜炎患儿和6例无菌性脑膜炎患儿,测定了血中Ne浓度。
Neopterin (Ne) has a molecular weight of 253 and is a metabolite from GTP (glutamyl transpeptidase). In vivo, Ne is generally believed to be produced by monocytes after activation of monocytes by releasing IFN-γ (interferon-γ) mainly along with activation of T cells in immune target cells. This article reports the authors’ determination of Ne concentration in cerebrospinal fluid (CSF) in children with meningitis to identify bacterial and aseptic meningitis. PARTICIPANTS AND METHODS: Ten cases (0-6 years) of bacterial meningitis with CSF and blood-finding pathogens were diagnosed; 9 children with negative CSF bacterial culture and clinically diagnosed aseptic meningitis (including Mumps in 4 cases, 0 to 7 years old). In the control group, there were 45 cases of non-central diseases such as urinary tract infection and those with non-inflammatory diseases such as epilepsy, which were suspicious for meningitis without abnormal CSF. In children with meningitis at admission and changes in the course of the disease, the concentration of Ne in CSF was measured many times and its peak value was compared. At the same time, on the same day of CSF determination, blood Ne concentration was measured in 9 children with bacterial meningitis and 6 children with aseptic meningitis.