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目的观察转换酶抑制剂（ＡＣＥＩ）苯那普利拉（Ｂｅｎａｚｅｐｒｉｌａｔ）对自发性高血压大鼠（ＳＨＲ）肾小球系膜细胞增殖的影响．方法采用细胞培养和３Ｈ－胸腺嘧啶核苷（３Ｈ－ＴｄＲ）参入技术．结果（１）血管紧张素Ⅱ（ＡｎｇⅡ）组的３Ｈ－ＴｄＲ参入率高于对照组；（２）ＡｎｇⅡ加Ｂｅｎａｚｅｐｒｉｌａｔ组的３Ｈ－ＴｄＲ参入率低于ＡｎｇⅡ组；（３）ＡｎｇⅡ对ＳＨＲ肾小球系膜细胞增殖的刺激作用和Ｂｅｎａｚｅｐｒｉｌａｔ的抑制作用呈剂量依赖关系．结论苯那普利拉能逆转ＡｎｇⅡ对ＳＨＲ肾小球系膜细胞的增殖作用，从细胞水平体现其肾脏保护作用．
Objective To investigate the effect of Benazeprilat, a converting enzyme inhibitor (ACEI), on the proliferation of mesangial cells in spontaneously hypertensive rats (SHR). Methods Cell culture and 3H-thymidine (3H-TdR) incorporation were used. Results (1) 3H-TdR incorporation rate in AngⅡ group was higher than that in control group. (2) 3H-TdR incorporation rate in AngⅡ plus Benazeprilat group was lower than that in AngⅡ group. (3) Stimulation of mesangial cell proliferation and Benazeprilat inhibition in a dose-dependent manner. Conclusion Benazepril can reverse the proliferation of SHR mesangial cells stimulated by AngⅡ, which shows its protective effect on kidney from cellular level.