Purpose:To provide initial validation of the Treatment Satisfaction Survey-Intraocular Pressure(TSS-IOP)quality-of-life survey that analyses specific issues related to side effects,patient satisfaction,and compliance.Methods:A prospective,observational cohort of 250 consecutive patients with primary open-angle glaucoma or ocular hypertension was administered the TSS-IOP survey.Results:Factors that correlated with patient satisfaction included perceived effectiveness of the medicine(F=7.47,P< 0.001),ocular irritation(F=6.06,P< 0.001),conjunctival hyperaemia(F=4.40,P< 0.001),ease of use(F=8.52,P< 0.001),and convenience of use(F=6.90,P < 0.001).Patient compliance,acceptance of their illness,and knowledge of glaucoma were also related to perceived effectiveness of the medicine(P < 0.001),ease of use(P < 0.05)and convenience(P < 0.001).Physician ratings of patient pressure control,side effects,and instillation problems also were significantly correlated to patient satisfaction(R=0.13=0.26,P=0.05-0.001).The physician ratings of patient compliance,however,were not significantly related to any dimension of patient satisfaction(P > 0.05).Among monotherapy prostaglandin treatments,latanoprost demonstrated statistically greater satisfaction than bimatoprost or travoprost regarding conjunctival hyperaemia(P < 0.05)and eye irritation(P < 0.01).Conclusions:This study provides initial evidence that patient satisfaction may be related to compliance,perceived effectiveness of treatment,adverse side effects,ease and convenience of use,acceptance of illness,and knowledge of glaucoma. Purpose: To provide initial validation of the Treatment Satisfaction Survey-Intraocular Pressure (TSS-IOP) quality-of-life survey that analyzes specific issues related to side effects, patient satisfaction, and compliance. Methods: A prospective, observational cohort of 250 consecutive patients with primary open-angle glaucoma or ocular hypertension was administered the TSS-IOP survey. Results: Factors that correlated with patient satisfaction included the perceived effectiveness of the medicine (F = 7.47, P <0.001), ocular irritation (F = 6.06, P (F = 4.40, P <0.001), ease of use (F = 8.52, P <0.001), and convenience of use (F = 6.90, P <0.001) .Pattern compliance, acceptance of their illness , and knowledge of glaucoma were also related to perceived effectiveness of the medicine (P <0.001), ease of use (P <0.05) and convenience (P <0.001) .Physician ratings of patient pressure control, side effects, and instillation problems also were significantly correlated to patient satisfaction (R = 0.13 = 0.26, P = 0.05-0.001). The physician ratings of patient compliance, however, were not significantly related to any dimension of patient satisfaction (P> 0.05) .Among monotherapy prostaglandin treatments, latanoprost of statistical features greater than bimatoprost or travoprost compliance conjunctival hyperaemia (P <0.05) and eye irritation (P <0.01) .Conclusions: This study provides initial evidence that patient satisfaction may, be perceived effectiveness of treatment, adverse side effects, ease and convenience of use, acceptance of illness, and knowledge of glaucoma.