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目的探讨监测老年脑梗死患者血清CRP、IL-6、TNF-α、TK、EAI的临床价值。方法选取老年脑梗死患者作为观察组,选取同期有可比性的老年健康体检者56例作为对照组,分别抽取前者治疗前后及后者肘静脉血,检测血清CRP、IL-6、TNF-α、TK、EAI,并进行比较分析。结果观察组患者入院早期CRP、IL-6、TNF-α、TK、EAI均明显高于对照组,两组患者比较差异有统计学意义,有可比性(P﹤0.05);经过治疗3个月后,观察组患者CRP、IL-6、TNF-α、TK、EAI略高于对照组,但比较差异无统计学意义,没有可比性(P﹥0.05);随着梗死面积及轻度神经功能缺损的加重,脑梗死患者血清CRP、IL-6、TNF-α含量明显提高,相同评价指标内,不同程度脑梗之间差异明显,差异有统计学意义(P﹤0.05)。结论通过监测血清CRP、IL-6、TNF-α、TK、EAI,对老年脑梗死患者的临床诊断有着积极意义,值得临床推广。
Objective To investigate the clinical value of serum CRP, IL-6, TNF-α, TK and EAI in senile patients with cerebral infarction. Methods Aged patients with cerebral infarction were selected as the observation group. Fifty-six elderly healthy volunteers were selected as the control group. The elbow venous blood was collected before and after treatment and the latter were collected. The levels of serum CRP, IL-6, TNF- TK, EAI, and comparative analysis. Results The levels of CRP, IL-6, TNF-α, TK and EAI in the observation group were significantly higher than those in the control group. There was significant difference between the two groups (P <0.05) The levels of CRP, IL-6, TNF-α, TK and EAI in the observation group were slightly higher than those in the control group, but the difference was not statistically significant (P> 0.05). With the infarction size and mild neurological function Decreased aggravate the content of serum CRP, IL-6 and TNF-α in patients with cerebral infarction. The difference was significant between different degree of cerebral infarction within the same evaluation index (P <0.05). Conclusion The monitoring of serum CRP, IL-6, TNF-α, TK, EAI has clinical significance in the diagnosis of elderly patients with cerebral infarction, and is worthy of clinical promotion.