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目的:探讨替米沙坦对急性心肌梗死冠脉介入治疗后心室重塑及炎性因子水平的影响。方法:整取抽样2015年6月至2016年6月在咸安区中医医院行冠脉介入术治疗的急性心肌梗死患者76例,按随机数字表法分为2组,对照组38例患者,术后第1d,开始服用培哚普利4mg/次,1次/d,观察组38例患者,服用替米沙坦80mg/次,1次/d,共治疗12周,治疗前后进行超声心动图检查,观察患者左室射血分数(LVEF)、左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV)水平变化,并测定治疗前后血清白介素-6(IL-6)水平、肿瘤坏死因子(TNF-α)变化。结果:观察组术后12周LVEF水平高于对照组,LVESV、LVEDV降低(P<0.05);观察组术后12周IL-6、TNF-α水平低于对照组(P<0.05)。结论:对行冠脉介入术治疗的急性心肌梗死患者采取替米沙坦治疗能改善左心室重塑,降低炎性因子水平,效果较好。
Objective: To investigate the effect of telmisartan on ventricular remodeling and inflammatory cytokines in patients with acute myocardial infarction after coronary intervention. Methods: From June 2015 to June 2016, 76 patients with acute myocardial infarction undergoing coronary intervention in the Chinese medicine hospital of Xiangan District were divided into two groups according to the random number table method, 38 patients in the control group, On the first postoperative day, patients were started taking perindopril 4mg / time, once a day, 38 patients in the observation group were treated with Telmisartan 80mg / time, once a day for 12 weeks. Echocardiography was performed before and after treatment The left ventricular ejection fraction (LVEF), left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV) were measured. The levels of serum interleukin-6 Changes in necrosis factor (TNF-α). Results: The levels of LVEF in observation group at 12 weeks after operation were significantly lower than those in control group (P <0.05). The levels of IL-6 and TNF-α in observation group at 12 weeks after operation were lower than those in control group (P <0.05). Conclusion: Telmisartan can improve left ventricular remodeling and reduce the level of inflammatory cytokines in patients with acute myocardial infarction undergoing coronary intervention.