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合成了氧青霉烷环,用Pd(AcO)2和Cs2CO3代替了Zn(AcO)2和DBU后,总收率比文献报道提高了一倍。初步证明氧青霉烷可抑制某些酵母样和丝状真菌生长,对KB细胞具有杀伤作用
The synthesis of oxanamido ring, with Pd (AcO) 2 and Cs2CO3 instead of Zn (AcO) 2 and DBU, the total yield than the literature reported doubled. It was initially proved that oxypenamycin can inhibit the growth of certain yeast-like and filamentous fungi and kill KB cells