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近年来由于厌氧培养技术的发展,有关感染根管微生物学研究有了明显突破,在感染根管中分离到各种厌氧的、兼性厌氧的和需氧的细菌,对于这些混合菌感染的研究及有效药物选择,是目前感兴趣的课题。本文在感染根管细菌学研究的基础上,讨论了临床常用药物,对与感染根管关系比较密切的细菌,如产黑色素拟杆菌,具核梭杆菌,干酪乳杆菌,口腔链球菌等的抗菌作用。其目的是为牙髓病和慢性根尖周病的临床治疗,在有效药物的选择方面提供实验依据。
In recent years, due to the development of anaerobic culture technology, there has been a clear breakthrough in microbiology research on infected root canals. A variety of anaerobic, facultatively anaerobic and aerobic bacteria are isolated from infected root canals. For these mixed bacteria Infection studies and effective drug selection are the topics of current interest. Based on the bacteriological study of root canal infection, this paper discusses the commonly used clinical drugs, bacteria that have close relationship with infected root canal, such as Bacteroides melanosis, Fusobacterium nucleatum, Lactobacillus casei and Streptococcus oralis effect. Its purpose is to provide clinical evidence for the treatment of endodontic disease and chronic apical disease, providing experimental evidence in the selection of effective drugs.