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虽然许多药物用于治疗哮喘,但有少数严重哮喘病人往往需要大剂量长时间皮质类固醇,这可引起患者许多并发症。出于寻找类固醇长期疗法代用品的需要,不少研究者试用其他药物,想使严重慢性哮喘病例能免受类固醇之苦。Mullafkey 等报道在严重哮喘无肺功能减退的患者应用抗炎药甲氨蝶呤可显著降低类固醇用量(平均降低36.5%)。本研究目的是查明甲氨蝶呤对严重类固醇依赖性哮喘患者的类固醇需要量、病人症状、气道反应、血细胞成分和
Although many drugs are used to treat asthma, a small number of patients with severe asthma often require large doses of prolonged corticosteroids, which can cause many complications in patients. In search of long-term alternatives to steroids, many researchers have tried other drugs to make the case of severe chronic asthma resistant to steroids. Mullafkey et al. Reported that the use of anti-inflammatory drug methotrexate significantly reduced steroid use (an average reduction of 36.5%) in patients with severe asthma without hypofunction. The aim of this study was to determine the effects of methotrexate on steroid requirements, patient symptoms, airway response, blood cell components, and plasma levels of patients with severe steroid-dependent asthma