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目的 探讨柠檬酸提取物抗体 (CAE- Ab)及烟碱型乙酰胆碱受体抗体 (n Ach R- Ab)测定对临床诊断重症肌无力 (MG)伴发胸腺瘤或胸腺增生患者的价值 ,及与改良 Osserman分型的关系。方法 采用酶联免疫吸附法检测 5 6例伴或不伴胸腺瘤、胸腺增生的 MG患者的血清 n Ach R- Ab、 CAE- Ab。结果 CAE- Ab阳性率 75 % ,n Ach R-Ab阳性率 71.4 3% ,大多为 a型、 b型与 型患者。结论 CAE- Ab及 n Ach R- Ab检测可作为临床诊断 MG患者伴发胸腺瘤或胸腺增生的筛选检查 ,并对病情的评估有一定的指导意义
Objective To investigate the value of determination of CAE-Ab and nAch R-Ab in clinical diagnosis of patients with myasthenia gravis (MG) complicated with thymoma or thymus hyperplasia, Improved Osserman classification of the relationship. Methods Serum nAch R-Ab and CAE-Ab in 56 MG patients with or without thymoma and thymus hyperplasia were detected by enzyme-linked immunosorbent assay. Results The positive rate of CAE-Ab was 75%, while the positive rate of nAch R-Ab was 71.4 3%. Most of them were type a, type b and type. Conclusion The detection of CAE-Ab and nAch R-Ab can be used as a screening test for clinical diagnosis of MG patients with thymoma or thymus hyperplasia, and has certain guiding significance for the evaluation of the disease