骨质疏松是绝经后妇女的一种严重疾病,并容易导致骨折。前期工作表明,脉冲性机械加载可以促进小鼠骨生长和骨损伤愈合。然而,我们的原创性脉冲性脊柱机械加载对小鼠骨质疏松的改善作用尚需探索。使用绝经后骨质疏松动物模型卵巢切除(OVX)小鼠,我们验证假设:脊柱机械加载通过促进成骨细胞的分化和抑制破骨细胞的发育治疗骨质疏松。C57BL/6雌性小鼠(14周龄)随机分为3组:假手术组,OVX对照 Osteoporosis is a serious disease in postmenopausal women and can easily lead to fractures. Preliminary work shows that pulsed mechanical loading can promote bone growth and bone healing in mice. However, the improvement of osteoporosis in mice induced by our original pulsed spinal mechanical loading remains to be explored. Using postmenopausal osteoporotic animal models of ovariectomized (OVX) mice, we validated the hypothesis that spinal mechanical loading treats osteoporosis by promoting the differentiation of osteoblasts and inhibiting the development of osteoclasts. C57BL / 6 female mice (14 weeks old) were randomly divided into 3 groups: sham operation group, OVX control