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人的血浆渗透压通常维持在290mOsm/kg左右。这是①血浆渗透压变化引起ADH的分泌调节,②口渴感引起饮水调节,③血浆ADH浓度变化影响尿浓缩稀释作用的综合结果。肾小球滤过的原尿在近曲小管等张性再吸收之后,到了亨利氏袢升支的粗段只进行氯化钠的再吸收,而使水不能透过,这样问质保持了NaCl,使间质维持在高渗状态。一旦血液渗透压升高刺激ADH分泌时,就会使集合管水透过性增强,尿液通过该处时,在渗透压梯度的作用下,水分从肾小管腔向维持高渗状态的
Human plasma osmolality is usually maintained at about 290mOsm / kg. This is ① changes in plasma osmotic pressure caused by the regulation of ADH secretion, ② thirst caused by drinking water regulation, ③ changes in plasma concentrations of ADH affect the concentration and dilution of urine results. Glomerular filtration of the original urine in the proximal convoluted tubule reabsorption, to the throat of Henry’s ascending branch of the only re-absorption of sodium chloride, leaving the water can not be transmitted, so ask to maintain the NaCl , To maintain the interstitial hypertonic state. Once the increase in blood pressure to stimulate the secretion of ADH, it will enhance the water through the manifold enhanced urine through the Department, under the effect of the osmotic pressure gradient, the water from the renal tubule to maintain hypertonic state