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目的探讨宫腔粘连分离术后患者自然周期和促绒毛膜性腺激素(hCG)日的内膜厚度对体外受精-胚胎移植(IVF-ET)治疗结局的影响。方法回顾性分析29个IVF/ICSI周期。根据自然周期排卵日内膜厚度不同将患者分为两组:a组17例,内膜厚度<8mm;b组12例,内膜厚度≥8mm。根据hCG日内膜的厚度不同将29例患者分为两组:A组11例,内膜厚度<8mm;B组18例,内膜厚度≥8mm。结果患者本身的自然周期排卵日内膜厚度与超排周期hCG日内膜厚度呈直线相关关系。a和b组患者临床妊娠率及种植率均无显著差异;A组临床妊娠率和种植率明显低于B组[(18.2%vs.55.0%)和(10.0%vs.41.6%)](P<0.05和P<0.01)。结论宫腔粘连分离术后患者自然周期的内膜厚度与hCG日内膜厚度密切相关;若hCG日的内膜厚度能达到≥8mm,临床妊娠率及种植率可以接近平均水平。
Objective To investigate the effect of intima-in-vitro fertilization-embryo transfer (IVF-ET) treatment on spontaneous cycle and the intimal thickening of hCG after intrauterine adhesions. Methods Retrospective analysis of 29 cycles of IVF / ICSI. The patients were divided into two groups according to the thickness of endometrial ovulation day: 17 cases in group a, the thickness of intima was less than 8 mm, and 12 cases in group b, the thickness of intima was more than or equal to 8 mm. 29 patients were divided into two groups according to the thickness of the intima of hCG day: 11 cases in group A, the thickness of intima was less than 8mm, and 18 cases in group B, the thickness of intima was more than or equal to 8mm. Results The patient’s own natural cycle ovulation intima-media thickness and the thickness of hCG superovulation cycle showed a linear correlation. There was no significant difference in clinical pregnancy rate and implantation rate between group a and group b. The clinical pregnancy rate and implantation rate in group A were significantly lower than those in group B [(18.2% vs.55.0%) and (10.0% vs.41.6%)] <0.05 and P <0.01). Conclusions The intima thickness of patients with intrauterine adhesions is closely related to the intima thickness of hCG. If the intima thickness of hCG can reach ≥8mm, the clinical pregnancy rate and implantation rate can approach the average level.